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1. ð å»çã»ããæ²»ç
ç¬ã®ãè¥æºçްèè «ããã¡ã©ããŒããã«å ç«ãã§ãã¯ãã€ã³ãæäœââã¡ã«ã¯ã®ç¬çšæPD-1æäœãã®ã«ãããããããå šç±³ã§æäŸéå§ãè «ççž®å°ã»å®å®ã¯7å²è¶
ð 2025.11
ã¡ã«ã¯ã»ã¢ããã«ãã«ã¹ã¯ãç¬å°çšã«èšèšãããå ç«ãã§ãã¯ãã€ã³ãé»å®³æäœãã®ã«ãããããïŒgilvetmabïŒããã2025幎11æã«ç±³åœã®è «çå°éå»åãã«å šç±³ã§æäŸéå§ãããã®ã«ãããããã¯ç¬ã®PD-1ïŒå ç«ã«ãã¬ãŒãããããååïŒãæšçãšããã«ããã€ãºãã»ã¢ãã¯ããŒãã«æäœã§ããã现èããããå ç«ã®ãã¬ãŒããå€ããäœèªèº«ã®å ç«ã«ãããæ»æããããç±³USDAãè¥æºçްèè «ïŒMCTïŒãšã¡ã©ããŒãïŒæªæ§é»è²è «ïŒãžã®äœ¿çšã«æ¡ä»¶ä»ãæ¿èªãäžããŠãããç£å»å ç§åŠå°éèªJVIMïŒ2026幎ïŒã«æå¹æ§ã»å®å šæ§ã®è©äŸ¡ãå ±åãããŠããã
åæè©Šéšã§ã¯ã20é±éã®æäžæéäžã«è¥æºçްèè «ã®ç¬ã®73%ãã¡ã©ããŒãã®ç¬ã®60%ã§è «çã®çž®å°ãŸãã¯ãç å¢ã®å®å®ïŒãã以äžå€§ãããªããªãç¶æ ïŒããåŸããããããã®ããæ²»çãäžå€ããããå ç«ãã§ãã¯ãã€ã³ãé»å®³ãããç¬ã§ãâ補åãšããŠâ䜿ããæä»£ãè¿ã¥ããæçŸ©ã¯å€§ãããçŸæç¹ã§ã¯è «çå°éå»ãéããŠã®ã¿å©çšã§ããããããããã«å¹ãããã§ã¯ãªãããæè¡ã»æŸå°ç·ã»æããå€ã«ç¶ããå ç«ãã®éžæè¢ãå ãããæç¬ã«MCTãã¡ã©ããŒããçãããããå°éå»ãžã®ç޹ä»ãå«ãæ²»çã®éžæè¢ã䞻治å»ãšçžè«ãããã
ð https://academic.oup.com/jvim/article/40/3/aalag098/8703156
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ç¬ã®ããããè¡æ¶²ã®ãã€ã¯ãRNAãã§æ©æã¹ã¯ãªãŒãã³ã°ââæ¥æ¬çºãmyRNA DOGsïŒãã€ã«ã ããã°ãºïŒããAIã§ç¶²çŸ è§£æ
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è¡æ¶²äžã«æµããå°ããªRNAååããã€ã¯ãRNAïŒmiRNAïŒãã®ãã¿ãŒã³ãããããã®æç¡ããªã¹ã¯ãæšå®ããââãããªç¬åãã®ããã¹ã¯ãªãŒãã³ã°æ€æ»ãmyRNA DOGsïŒãã€ã«ã ããã°ãºïŒããæ¥æ¬ã§ç»å Žãããã¢ãŒã¯ã¬ã€ç€Ÿãªã©ãæããããã®ã§ãå°éã®è¡æŒ¿ã«å«ãŸããmiRNAãç¶²çŸ çã«æž¬å®ããæ©æ¢°åŠç¿ïŒAIïŒã§ããã«é¢é£ãããã¿ãŒã³ãèªã¿åãã2026å¹Žã®æ¥æ¬ç£å»å ç§åŠã¢ã«ãããŒåŠè¡å€§äŒïŒJCVIM 2026ïŒã§ã¯ãæ¥æ¬åç©é«åºŠå»çã»ã³ã¿ãŒïŒJARMeCïŒã®éå£ä¿èŒå»åž«ããããã®æ€æ»ãå®èšåºã§äœ¿ã£ãçµéšãå ±åããã
ç¬ã¯äžèª¿ãé ããã¡ã§ãããã¯çç¶ãåºããšãã«ã¯é²è¡ããŠããããšãå€ããè¡æ¶²ãæ¡ãã ãã§äœãžã®è² æ ãå°ãªããå¥åº·èšºæã«çµã¿èŸŒã¿ãããã®ãmiRNAæ€æ»ã®å©ç¹ã ãããã§ã¯è¡äžãã€ã¯ãRNAã§è€æ°ã®ãããé«ç²ŸåºŠã«èŠåããç ç©¶ãé²ãã§ããããã®èãæ¹ãç¬ã«å¿çšãã圢ã«ãªãããã ãã¹ã¯ãªãŒãã³ã°æ€æ»ã¯ã確å®èšºæãã§ã¯ãªããéœæ§ãªãç»åæ€æ»ãªã©ã®ç²Ÿå¯æ€æ»ã§ç¢ºãããå¿ èŠããããé«éœ¢ç¬ãããã«ãªããããç¬çš®ã§ã¯ãããããæ°ããæ€æ»ãéžæè¢ã«å ¥ãã€ã€ã宿å¥èšºã§æ©æçºèŠã«åªãããã
ð https://arkraythinkanimal.com/post_lp/myrnadogs/
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3. 𧬠ç ç©¶ã»ç§åŠ
ç¬ã®è¡ç®¡èè «ããéºäŒåãã§èªã¿è§£ãââPTENã»p53å€ç°ã¯äºåŸäžè¯ãNRASå€ç°ã¯è¯å¥œãp53å€ç°ã«ã¯ã©ããã€ã·ã³ïŒããªãã¹ã¿ãããæå¹ã®å¯èœæ§ïŒVCO 2026ïŒ
ð 2026
è¡ç®¡èè «ïŒããã³ãžãªãµã«ã³ãŒããHSAïŒã¯èŸèãå¿èãªã©ã«ã§ããæªæ§ã®è¡ç®¡è «çã§ã墿®ãéãæ©æã«è»¢ç§»ããåŸæ¥ã®æ²»çãå¹ãã«ãã飿µã ã2026幎ã«Veterinary and Comparative Oncologyã«æ²èŒããã系統çã¬ãã¥ãŒïŒ51ç ç©¶ãè©äŸ¡ïŒã¯ã蚺æã»äºåŸã»æ²»çã®ããã€ãªããŒã«ãŒïŒç®å°ãšãªãååïŒããæŽçãããé¢é£ããå®ããŒã¿ç ç©¶ã§ã¯ãæ²»çæ³ã«ãããããPTENã»p53ïŒTP53ïŒå€ç°ãäºåŸäžè¯ã®ææšãNRASå€ç°ã¯ãããäºåŸè¯å¥œã®ææšã§ããããšã瀺ãããè «çã®éºäŒåãããã£ãŒã«ãçµéãå·Šå³ããããšãåãã£ãŠããã
ããã«æ³šç®ãããã®ã¯ãp53å€ç°ã®ããè¡ç®¡èè «ã§ã¯ãmTORé»å®³è¬ã©ããã€ã·ã³ãHDACé»å®³è¬ããªãã¹ã¿ãããæ²»çã«å ãããšå šçåãæ¹åããããšããç¥èŠã ãããã¯ãã©ã®ç¬ã«ã©ã®è¬ãå¹ãããããããéºäŒåã§èŠåããâ粟å¯è «çåŠïŒãã¬ã·ãžã§ã³ã»ãªã³ã³ããžãŒïŒâãžã®äžæ©ãæå³ãããè¡ç®¡èè «ã¯çªç¶ã®è ¹è å åºè¡ã§èŠã€ããããšãå€ããæ©æçºèŠãé£ããããã ãã«ãéºäŒåæ å ±ãæŽ»ãããæ²»çã®åå¥åãæåŸ ããããèŸèã®è «ããåå äžæã®è²§è¡ã»èè±ãã¿ãããããæ©æ¥ã«ç»åæ€æ»ãåããŠã»ããã
ð https://onlinelibrary.wiley.com/doi/10.1111/vco.70057
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4. ðïž å»çã»ããæ²»ç
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ð 2024
èéå¢ã¢ãã¯ãªã³è ºçïŒAGASACAïŒã¯ãèéã®ããã«ãããèéå¢ãããçºçããæªæ§è «çã§ãè¿ãã®ãªã³ãç¯ãžè»¢ç§»ãããããé²è¡ãããšæäŸ¿å°é£ãé«ã«ã«ã·ãŠã è¡çãåŒãèµ·ãããæšæºæ²»çã¯åçºå·£ãšè»¢ç§»ãªã³ãç¯ã®å€ç§çæåºã§ãæŸå°ç·ãæããå€ãçµã¿åãããéåŠçæ²»çãè¡ããããç ç©¶ã§ã¯ãæŸå°ç·ãåç¬ãŸãã¯è£å©çã«çšããå Žåã«çåæéã®äžå€®å€ã22ã32ã«æãšå ±åãããæè¡ã»æŸå°ç·ã»ååŠçæ³ããã¹ãŠè¡ã£ãé²è¡äŸã§ãå¹³å2.5å¹Žè¶ ã®çåã瀺ãããŠãããè¿å¹Žã¯ã20ã°ã¬ã€ã5åé£ç¶ã§åå²ç §å°ãããç·©åçãããã³ã«ã®æçžŸãšå¯äœçšãå ±åãããã
å°ãªãåæ°ã§ç §å°ããç·©åçæŸå°ç·ã¯ãéé¢ã麻é ã®è² æ ãæãã€ã€ãè «çã«ããçã¿ãæäŸ¿é害ãšãã£ãçç¶ããããããããšãçããäºåŸãå·Šå³ããã®ã¯åçºè «çã®å€§ãããå蚺æã®ãªã³ãç¯è»¢ç§»ã®æç¡ãæ°ãé é転移ãçµç¹åŠçãªæªæ§åºŠãªã©ã ãAGASACAã¯ãèéåšå²ãæ°ã«ãããã䟿ã现ãããæäŸ¿æã«çããããšãã£ããµã€ã³ããå¥åº·èšºæã®è§Šèšºã»ãšã³ãŒã§èŠã€ããããšããããæ°ã«ãªãçç¶ãããã°æ©ãã«å蚺ããå€ç§ã»æŸå°ç·ã»å ç§ãçµã¿åãããæ²»çèšç»ãå°éå»ãšçžè«ãããã
ð https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11125963/
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5. ð± å»çã»ããæ²»ç
ç«ã®ãã¯ã¯ãã³é¢é£èè «ïŒæ³šå°éšäœèè «ïŒãââåºç¯åé€ãåºæ¬ãéæè¶ 鳿³¢âãã¹ãããªãã·ãŒâãªã©äœäŸµè¥²æ²»çã®ç ç©¶ã
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ç«ã®æ³šå°éšäœèè «ïŒFISSãã¯ã¯ãã³é¢é£èè «ïŒã¯ãã¯ã¯ãã³ã泚å°ããã£ããã«æ¥çš®éšäœã®ä»è¿ã«çºçããããšãããæªæ§è «çã§ãçç¬ç ã»ç«çœè¡ç ã¯ã¯ãã³ãªã©ãšã®é¢é£ãææãããŠãããæ²»çã®åºæ¬ã¯ãåºãç¯å²ã倧ããåãåããç©æ¥µçãªå€ç§åé€ã ããæç«¯é°æ§ã§ãçŽ3åã®1ã§åçºãããšãããæŸå°ç·ã»å ç«çæ³ã»ååŠçæ³ãçµã¿åããããšäºåŸãæ¹åãããæ¬§å·ã®ABCDïŒç«ã®ææç察çå§å¡äŒïŒã¯2024幎ã«äºé²ãšç®¡çã®ã¬ã€ãã©ã€ã³ãæŽæ°ãããªã¹ã¯ã®é«ãéšäœãé¿ããæ¥çš®ãããããã®æ©æè©äŸ¡ã®éèŠæ§ã瀺ããŠããã
è¿å¹Žã¯ãäœãåããã«è «çãå£ãããã¹ãããªãã·ãŒïŒéæè¶ 鳿³¢ã«ããæ©æ¢°çã¢ãã¬ãŒã·ã§ã³ïŒããç«ã®FISSã«å¿çšããåæã®å®çŸå¯èœæ§ç ç©¶ãå ±åãããäœäŸµè¥²æ²»çã®å¯èœæ§ãæ¢ãããŠããã飌ãäž»ã«ã§ããæåã®å¯Ÿçã¯ãæ©æçºèŠãã ãæ¥çš®åŸã«ã§ãããããã1ã«æä»¥äžæ®ãã2cm以äžã«å€§ãããªãã3ã«æä»¥äžç¶ãå Žåã¯ãæŸçœ®ããç²Ÿå¯æ€æ»ãåããïŒãããã3-2-1ã«ãŒã«ïŒãã¯ã¯ãã³ã¯ææçäºé²ã«äžå¯æ¬ ã§éåºŠã«æããå¿ èŠã¯ãªãããæ¥çš®éšäœã®ãããã«ã¯æ³šæãæããæ°ã¥ãããæ©ãã«ç£å»åž«ãžçžè«ãã
ð https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148925/
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